A developmentally regulated switch regenerative growth of Schwann cells through cyclin D1

Haesun A. Kim, Scott L. Pomeroy, Wendy Whoriskey, Inka Pawlitzky, Larry I. Benowitz, Piotr Sicinski, Charles D. Stiles, Thomas M. Roberts

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Sciatic nerve axons in cyclin D1 knockout mice develop normally, become property ensheathed by Schwann cells, and appear to function normally. However, in the Wallerian degeneration model of nerve injury, the mitotic response of Schwann cells is completely inhibited. The mitotic block is Schwann cell autonomous and developmentally regulated. Rescue analysis (by 'knockin' of cyclin E) indicates that D1 protein, rather than regulatory elements of the D1 gene, provides the essential Schwann cell function. Genetic inhibition of the Schwann cell cycle shows that neuronal responses to nerve injury are surprisingly independent of Schwann cell mitotic responses. Even axonal regrowth into the distal zone of a nerve crush injury is not markedly impaired in cyclin D1(-/-) mice.

Original languageEnglish (US)
Pages (from-to)405-416
Number of pages12
JournalNeuron
Volume26
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'A developmentally regulated switch regenerative growth of Schwann cells through cyclin D1'. Together they form a unique fingerprint.

Cite this