A diffusible molecule may mediate glutamate neurotoxicity

Carlos H. Zambrano; Arnold G. Hyndman

doi:10.1016/0165-3806(83)90038-X

A diffusible molecule may mediate glutamate neurotoxicity

Carlos H. Zambrano, Arnold G. Hyndman

School of Arts and Sciences, Cell Biology & Neuroscience

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Purified neuronal cultures from 8-day chick embryo neural retinas were incubated in either serum-free N1 or N1 supplemented with heart extract. The addition of glutamate decreased neuronal survival only in the presence of heart extract; however, if heart extract was dialyzed, neuronal survival remained at control values. This suggests a diffusible molecule may mediate glutamate neurotoxicity. Kainic acid decreased neuronal survival in all conditions tested.

Original language	English (US)
Pages (from-to)	396-398
Number of pages	3
Journal	Developmental Brain Research
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/0165-3806(83)90038-X
State	Published - Sep 1983

All Science Journal Classification (ASJC) codes

Developmental Neuroscience
Developmental Biology

Keywords

glutamate
kainic acid
neuronal cultures
neurotoxicity
retina

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10.1016/0165-3806(83)90038-X

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title = "A diffusible molecule may mediate glutamate neurotoxicity",

abstract = "Purified neuronal cultures from 8-day chick embryo neural retinas were incubated in either serum-free N1 or N1 supplemented with heart extract. The addition of glutamate decreased neuronal survival only in the presence of heart extract; however, if heart extract was dialyzed, neuronal survival remained at control values. This suggests a diffusible molecule may mediate glutamate neurotoxicity. Kainic acid decreased neuronal survival in all conditions tested.",

keywords = "glutamate, kainic acid, neuronal cultures, neurotoxicity, retina",

author = "Zambrano, {Carlos H.} and Hyndman, {Arnold G.}",

note = "Funding Information: This work was supported by Grant PRM 8212393 from the National Science Foundation, and a Biomedical Research Support Grant PHS RR 07058-17.",

year = "1983",

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doi = "10.1016/0165-3806(83)90038-X",

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T1 - A diffusible molecule may mediate glutamate neurotoxicity

AU - Zambrano, Carlos H.

AU - Hyndman, Arnold G.

N1 - Funding Information: This work was supported by Grant PRM 8212393 from the National Science Foundation, and a Biomedical Research Support Grant PHS RR 07058-17.

PY - 1983/9

Y1 - 1983/9

N2 - Purified neuronal cultures from 8-day chick embryo neural retinas were incubated in either serum-free N1 or N1 supplemented with heart extract. The addition of glutamate decreased neuronal survival only in the presence of heart extract; however, if heart extract was dialyzed, neuronal survival remained at control values. This suggests a diffusible molecule may mediate glutamate neurotoxicity. Kainic acid decreased neuronal survival in all conditions tested.

AB - Purified neuronal cultures from 8-day chick embryo neural retinas were incubated in either serum-free N1 or N1 supplemented with heart extract. The addition of glutamate decreased neuronal survival only in the presence of heart extract; however, if heart extract was dialyzed, neuronal survival remained at control values. This suggests a diffusible molecule may mediate glutamate neurotoxicity. Kainic acid decreased neuronal survival in all conditions tested.

KW - glutamate

KW - kainic acid

KW - neuronal cultures

KW - neurotoxicity

KW - retina

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ER -

A diffusible molecule may mediate glutamate neurotoxicity

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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