A diffusible molecule may mediate glutamate neurotoxicity

Carlos H. Zambrano, Arnold G. Hyndman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purified neuronal cultures from 8-day chick embryo neural retinas were incubated in either serum-free N1 or N1 supplemented with heart extract. The addition of glutamate decreased neuronal survival only in the presence of heart extract; however, if heart extract was dialyzed, neuronal survival remained at control values. This suggests a diffusible molecule may mediate glutamate neurotoxicity. Kainic acid decreased neuronal survival in all conditions tested.

Original languageEnglish (US)
Pages (from-to)396-398
Number of pages3
JournalDevelopmental Brain Research
Issue number3
StatePublished - Sep 1983

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology


  • glutamate
  • kainic acid
  • neuronal cultures
  • neurotoxicity
  • retina


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