A-esterase

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A-esterase, more popularly known as paraoxonase (EC 3.1.8.1), is a family of enzymes, one of which breaks down the toxic, metabolically activated oxygen analogs of a handful of organophosphorus insecticides and nerve gases. Paraoxonase probably plays a role in the detoxification of these chemicals at high exposure levels, but likely is less important than other detoxification pathways following low insecticide exposure levels. In recent years, studies have suggested that paraoxonases have some role in the prevention of oxidative stress and inflammation, and have implicated these enzymes in the modulation of a wide variety of diseases, including atherosclerosis, diabetes, Parkinson's disease, and inflammatory bowel disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Toxicology
Subtitle of host publicationThird Edition
PublisherElsevier
Pages102-103
Number of pages2
ISBN (Electronic)9780123864543
ISBN (Print)9780123864550
DOIs
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Chlorpyrifos
  • Diazinon
  • Dichlorvos
  • Methyl parathion
  • Organophosphorus pesticides
  • Paraoxonase
  • Parathion
  • Pirimiphos methyl

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