A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length

M. Mangino, J. B. Richards, N. Soranzo, G. Zhai, A. Aviv, A. M. Valdes, N. J. Samani, P. Deloukas, T. D. Spector

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Background: Telomere length is a predictor for a number of common age related diseases and is a heritable trait. Methods and results: To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314 075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined = 2790). We identified two novel associated variants (rs2162440, p = 2.6 × 10 -6; and rs7235755, p = 5.5 × 10-6) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast. Conclusion: These results provide new insights into the pathways regulating telomere homeostasis in humans.

Original languageEnglish (US)
Pages (from-to)451-454
Number of pages4
JournalJournal of medical genetics
Volume46
Issue number7
DOIs
StatePublished - Jul 2009

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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