A laminin 511 matrix is regulated by Taz and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells

Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju McKee, Peter D. Yurchenco, Arthur M. Mercurio

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes selfrenewal and tumor initiation by engaging the a6Bb1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the a5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalGenes and Development
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Keywords

  • Cancer stem cell
  • Extracellular matrix
  • Integrin
  • Laminin
  • TAZ

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