A laminin 511 matrix is regulated by Taz and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells

Cheng Chang; Hira Lal Goel; Huijie Gao; Bryan Pursell; Leonard D. Shultz; Dale L. Greiner; Sulev Ingerpuu; Manuel Patarroyo; Shiliang Cao; Elgene Lim; Junhao Mao; Karen Kulju McKee; Peter D. Yurchenco; Arthur M. Mercurio

doi:10.1101/gad.253682.114

A laminin 511 matrix is regulated by Taz and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells

Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju McKee, Peter D. Yurchenco, Arthur M. Mercurio

RWJ-Pathology-PISC

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes selfrenewal and tumor initiation by engaging the a6Bb1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the a5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Genes and Development
Volume	29
Issue number	1
DOIs	https://doi.org/10.1101/gad.253682.114
State	Published - Jan 1 2015

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

Keywords

Cancer stem cell
Extracellular matrix
Integrin
Laminin
TAZ

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Chang, C., Goel, H. L., Gao, H., Pursell, B., Shultz, L. D., Greiner, D. L., Ingerpuu, S., Patarroyo, M., Cao, S., Lim, E., Mao, J., Kulju McKee, K., Yurchenco, P. D., & Mercurio, A. M. (2015). A laminin 511 matrix is regulated by Taz and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells. Genes and Development, 29(1), 1-6. https://doi.org/10.1101/gad.253682.114

Chang, Cheng ; Goel, Hira Lal ; Gao, Huijie ; Pursell, Bryan ; Shultz, Leonard D. ; Greiner, Dale L. ; Ingerpuu, Sulev ; Patarroyo, Manuel ; Cao, Shiliang ; Lim, Elgene ; Mao, Junhao ; Kulju McKee, Karen ; Yurchenco, Peter D. ; Mercurio, Arthur M. / A laminin 511 matrix is regulated by Taz and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells. In: Genes and Development. 2015 ; Vol. 29, No. 1. pp. 1-6.

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title = "A laminin 511 matrix is regulated by Taz and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells",

abstract = "Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes selfrenewal and tumor initiation by engaging the a6Bb1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the a5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer.",

keywords = "Cancer stem cell, Extracellular matrix, Integrin, Laminin, TAZ",

author = "Cheng Chang and Goel, {Hira Lal} and Huijie Gao and Bryan Pursell and Shultz, {Leonard D.} and Greiner, {Dale L.} and Sulev Ingerpuu and Manuel Patarroyo and Shiliang Cao and Elgene Lim and Junhao Mao and {Kulju McKee}, Karen and Yurchenco, {Peter D.} and Mercurio, {Arthur M.}",

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doi = "10.1101/gad.253682.114",

language = "English (US)",

volume = "29",

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Chang, C, Goel, HL, Gao, H, Pursell, B, Shultz, LD, Greiner, DL, Ingerpuu, S, Patarroyo, M, Cao, S, Lim, E, Mao, J, Kulju McKee, K, Yurchenco, PD & Mercurio, AM 2015, 'A laminin 511 matrix is regulated by Taz and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells', Genes and Development, vol. 29, no. 1, pp. 1-6. https://doi.org/10.1101/gad.253682.114

A laminin 511 matrix is regulated by Taz and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells. / Chang, Cheng; Goel, Hira Lal; Gao, Huijie; Pursell, Bryan; Shultz, Leonard D.; Greiner, Dale L.; Ingerpuu, Sulev; Patarroyo, Manuel; Cao, Shiliang; Lim, Elgene; Mao, Junhao; Kulju McKee, Karen; Yurchenco, Peter D.; Mercurio, Arthur M.

In: Genes and Development, Vol. 29, No. 1, 01.01.2015, p. 1-6.

Research output: Contribution to journal › Article › peer-review

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AU - Chang, Cheng

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AU - Gao, Huijie

AU - Pursell, Bryan

AU - Shultz, Leonard D.

AU - Greiner, Dale L.

AU - Ingerpuu, Sulev

AU - Patarroyo, Manuel

AU - Cao, Shiliang

AU - Lim, Elgene

AU - Mao, Junhao

AU - Kulju McKee, Karen

AU - Yurchenco, Peter D.

AU - Mercurio, Arthur M.

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AB - Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes selfrenewal and tumor initiation by engaging the a6Bb1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the a5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer.

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