A novel lignan, guaiacylglycerol-β-O-6'-(2-methoxy)cinnamyl alcohol ether, three known simaroubolides, brusatol, dehydrobrusatol, yadanziolide C, and the known terpenoid, blumenol A, were obtained as active compounds from an ethyl acetate-soluble extract of Brucea javanica, using a bioassay based on the induction of cell differentiation with human promyelocytic leukemia (HL-60) cells. Also obtained were the known coumarinolignan, cleomiscosin A, and the known quassinoid glycoside, bruceoside B, which were inactive in the HL-60 cell test system. The structure of the new lignan was determined by a combination of 1D and 2D NMR techniques.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Plant Science
- Brucea javanica
- cell differentiation
- guaiacylglycerol-β-O-6'-(2- methoxy)cinnamyl alcohol ether
- human promyelocytic leukemia (HL-60) cells