A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells

Lumonadio Luyengi, Nanjoo Suh, Harry H.S. Fong, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

A novel lignan, guaiacylglycerol-β-O-6'-(2-methoxy)cinnamyl alcohol ether, three known simaroubolides, brusatol, dehydrobrusatol, yadanziolide C, and the known terpenoid, blumenol A, were obtained as active compounds from an ethyl acetate-soluble extract of Brucea javanica, using a bioassay based on the induction of cell differentiation with human promyelocytic leukemia (HL-60) cells. Also obtained were the known coumarinolignan, cleomiscosin A, and the known quassinoid glycoside, bruceoside B, which were inactive in the HL-60 cell test system. The structure of the new lignan was determined by a combination of 1D and 2D NMR techniques.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalPhytochemistry
Volume43
Issue number2
DOIs
StatePublished - Sep 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Keywords

  • Brucea javanica
  • Simaroubaceae
  • cell differentiation
  • guaiacylglycerol-β-O-6'-(2- methoxy)cinnamyl alcohol ether
  • human promyelocytic leukemia (HL-60) cells
  • lignan
  • seeds
  • simaroubolides

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