A linkage study between the GABAA β2 and GABAA γ2 subunit genes and major psychoses

Alda M. Ambrósio, James L. Kennedy, Fabio Macciardi, Nicole King, Maria H. Azevedo, Catarina R. Oliveira, Carlos N. Pato

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABAA) β2 and GABAA γ2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABAA: NPL narrow=-0.450; NPL broad=-0.808; GABAA γ2: NPL narrow=0.177; NPL broad=-0.051) or bipolar disorder (GABAA β2: NPL narrow=0.834; NPL broad=0.783; GABAA γ2: NPL narrow=-0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABAA β2 and GABAA γ2 genes are significantly linked to major psychoses in a Portuguese population.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalCNS Spectrums
Issue number1
StatePublished - Jan 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health


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