A linkage study between the GABAA β2 and GABAA γ2 subunit genes and major psychoses

Alda M. Ambrósio; James L. Kennedy; Fabio Macciardi; Nicole King; Maria H. Azevedo; Catarina R. Oliveira; Carlos N. Pato

doi:10.1017/s1092852900009913

A linkage study between the GABA_A β₂ and GABA_A γ₂ subunit genes and major psychoses

Alda M. Ambrósio, James L. Kennedy, Fabio Macciardi, Nicole King, Maria H. Azevedo, Catarina R. Oliveira, Carlos N. Pato

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABA_A) β₂ and GABA_A γ₂ subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABA_A: NPL narrow=-0.450; NPL broad=-0.808; GABA_A γ₂: NPL narrow=0.177; NPL broad=-0.051) or bipolar disorder (GABA_A β2: NPL narrow=0.834; NPL broad=0.783; GABA_A γ2: NPL narrow=-0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABA_A β₂ and GABA_A γ₂ genes are significantly linked to major psychoses in a Portuguese population.

Original language	English (US)
Pages (from-to)	57-61
Number of pages	5
Journal	CNS Spectrums
Volume	10
Issue number	1
DOIs	https://doi.org/10.1017/s1092852900009913
State	Published - Jan 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Neurology
Psychiatry and Mental health

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title = "A linkage study between the GABAA β2 and GABAA γ2 subunit genes and major psychoses",

abstract = "Background: Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABAA) β2 and GABAA γ2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABAA: NPL narrow=-0.450; NPL broad=-0.808; GABAA γ2: NPL narrow=0.177; NPL broad=-0.051) or bipolar disorder (GABAA β2: NPL narrow=0.834; NPL broad=0.783; GABAA γ2: NPL narrow=-0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABAA β2 and GABAA γ2 genes are significantly linked to major psychoses in a Portuguese population.",

author = "Ambr{\'o}sio, {Alda M.} and Kennedy, {James L.} and Fabio Macciardi and Nicole King and Azevedo, {Maria H.} and Oliveira, {Catarina R.} and Pato, {Carlos N.}",

year = "2005",

month = jan,

doi = "10.1017/s1092852900009913",

language = "English (US)",

volume = "10",

pages = "57--61",

journal = "CNS Spectrums",

issn = "1092-8529",

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T1 - A linkage study between the GABAA β2 and GABAA γ2 subunit genes and major psychoses

AU - Ambrósio, Alda M.

AU - Kennedy, James L.

AU - Macciardi, Fabio

AU - King, Nicole

AU - Azevedo, Maria H.

AU - Oliveira, Catarina R.

AU - Pato, Carlos N.

PY - 2005/1

Y1 - 2005/1

N2 - Background: Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABAA) β2 and GABAA γ2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABAA: NPL narrow=-0.450; NPL broad=-0.808; GABAA γ2: NPL narrow=0.177; NPL broad=-0.051) or bipolar disorder (GABAA β2: NPL narrow=0.834; NPL broad=0.783; GABAA γ2: NPL narrow=-0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABAA β2 and GABAA γ2 genes are significantly linked to major psychoses in a Portuguese population.

AB - Background: Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABAA) β2 and GABAA γ2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABAA: NPL narrow=-0.450; NPL broad=-0.808; GABAA γ2: NPL narrow=0.177; NPL broad=-0.051) or bipolar disorder (GABAA β2: NPL narrow=0.834; NPL broad=0.783; GABAA γ2: NPL narrow=-0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABAA β2 and GABAA γ2 genes are significantly linked to major psychoses in a Portuguese population.

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A linkage study between the GABA_A β₂ and GABA_A γ₂ subunit genes and major psychoses

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