A model evaluation study for treatment planning of laser-induced thermal therapy

Samuel J. Fahrenholtz, Tim Y. Moon, Michael Franco, David Medina, Shabbar Danish, Ashok Gowda, Anil Shetty, Florian Maier, John D. Hazle, Roger J. Stafford, Tim Warburton, David Fuentes

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A cross-validation analysis evaluating computer model prediction accuracy for a priori planning magnetic resonance-guided laser-induced thermal therapy (MRgLITT) procedures in treating focal diseased brain tissue is presented. Two mathematical models are considered. (1) A spectral element discretisation of the transient Pennes bioheat transfer equation is implemented to predict the laser-induced heating in perfused tissue. (2) A closed-form algorithm for predicting the steady-state heat transfer from a linear superposition of analytic point source heating functions is also considered. Prediction accuracy is retrospectively evaluated via leave-one-out cross-validation (LOOCV). Modelling predictions are quantitatively evaluated in terms of a Dice similarity coefficient (DSC) between the simulated thermal dose and thermal dose information contained within N = 22 MR thermometry datasets. During LOOCV analysis, the transient models DSC mean and median are 0.7323 and 0.8001 respectively, with 15 of 22 DSC values exceeding the success criterion of DSC ≥ 0.7. The steady-state models DSC mean and median are 0.6431 and 0.6770 respectively, with 10 of 22 passing. A one-sample, one-sided Wilcoxon signed-rank test indicates that the transient finite element method model achieves the prediction success criteria, DSC ≥ 0.7, at a statistically significant level.

Original languageEnglish (US)
Pages (from-to)705-714
Number of pages10
JournalInternational Journal of Hyperthermia
Issue number7
StatePublished - Oct 3 2015

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)
  • Cancer Research


  • Bioheat transfer
  • MR temperature imaging
  • graphics processing unit (GPU)
  • laser induced thermal therapy


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