A molecular map of T cell development

Derek B. Sant'Angelo, Bruno Lucas, P. Greg Waterbury, Beth Cohen, Thea Brabb, Joan Goverman, Ronald N. Germain, Charles A. Janeway

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Using a sensitive molecular marker for positive selection, the appearance of a particular functional TCR α chain sequence in cells from mice bearing a transgenic β chain, we address several aspects of intrathymic T cell development. First, by examining specific TCR prior to and after maturation, we demonstrate how a restricted TCR repertoire is positively selected from a highly diverse immature TCR repertoire. Second, since this molecular marker is enriched in cells progressing toward the CD4 lineage and depleted in cells progressing toward the CD8 lineage, a map of the developmental pathway of αβ thymocytes can be inferred. Third, the first cells that show clear signs of positive intrathymic selection are identified.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
Issue number2
StatePublished - Aug 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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