A molecular model for proflavine-DNA intercalation

S. Neidle, L. H. Pearl, P. Herzyk, Helen M. Berman

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


A molecular model has been derived for the intercalation of proflavine into the CpG site of the decamer duplex of d(GATACGATAC). The starting geometry of the intercalation site was taken from previous crystallographic studies on the d(CpG)-proflavine complex, and molecular mechanics used to obtain a stereocheracally acceptable structure. This has widened grooves compared to standard A- or B- double helices, as well as distinct conformational, roll, twist and tilt features.

Original languageEnglish (US)
Pages (from-to)8999-9015
Number of pages17
JournalNucleic acids research
Issue number18
StatePublished - Sep 26 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

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