A molecular model for proflavine-DNA intercalation

S. Neidle; L. H. Pearl; P. Herzyk; Helen M. Berman

doi:10.1093/nar/16.18.8999

A molecular model for proflavine-DNA intercalation

S. Neidle
, L. H. Pearl
, P. Herzyk
, Helen M. Berman

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A molecular model has been derived for the intercalation of proflavine into the CpG site of the decamer duplex of d(GATACGATAC). The starting geometry of the intercalation site was taken from previous crystallographic studies on the d(CpG)-proflavine complex, and molecular mechanics used to obtain a stereocheracally acceptable structure. This has widened grooves compared to standard A- or B- double helices, as well as distinct conformational, roll, twist and tilt features.

Original language	English (US)
Pages (from-to)	8999-9015
Number of pages	17
Journal	Nucleic acids research
Volume	16
Issue number	18
DOIs	https://doi.org/10.1093/nar/16.18.8999
State	Published - Sep 26 1988
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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10.1093/nar/16.18.8999

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title = "A molecular model for proflavine-DNA intercalation",

abstract = "A molecular model has been derived for the intercalation of proflavine into the CpG site of the decamer duplex of d(GATACGATAC). The starting geometry of the intercalation site was taken from previous crystallographic studies on the d(CpG)-proflavine complex, and molecular mechanics used to obtain a stereocheracally acceptable structure. This has widened grooves compared to standard A- or B- double helices, as well as distinct conformational, roll, twist and tilt features.",

author = "S. Neidle and Pearl, \{L. H.\} and P. Herzyk and Berman, \{Helen M.\}",

note = "Funding Information: ACKNOWLEDGEMENTS We are grateful to the Cancer Research Campaign for support to SN and for providing a visiting Fellowship to PH. Richard Dickerson is thanked for provision of his helix analysis program. HMB is grateful for support from grants NIH GM21589, CA06927, RR05539, and from an appropriation of the Commonwealth of Pennsylvania.",

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doi = "10.1093/nar/16.18.8999",

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T1 - A molecular model for proflavine-DNA intercalation

AU - Neidle, S.

AU - Pearl, L. H.

AU - Herzyk, P.

AU - Berman, Helen M.

N1 - Funding Information: ACKNOWLEDGEMENTS We are grateful to the Cancer Research Campaign for support to SN and for providing a visiting Fellowship to PH. Richard Dickerson is thanked for provision of his helix analysis program. HMB is grateful for support from grants NIH GM21589, CA06927, RR05539, and from an appropriation of the Commonwealth of Pennsylvania.

PY - 1988/9/26

Y1 - 1988/9/26

N2 - A molecular model has been derived for the intercalation of proflavine into the CpG site of the decamer duplex of d(GATACGATAC). The starting geometry of the intercalation site was taken from previous crystallographic studies on the d(CpG)-proflavine complex, and molecular mechanics used to obtain a stereocheracally acceptable structure. This has widened grooves compared to standard A- or B- double helices, as well as distinct conformational, roll, twist and tilt features.

AB - A molecular model has been derived for the intercalation of proflavine into the CpG site of the decamer duplex of d(GATACGATAC). The starting geometry of the intercalation site was taken from previous crystallographic studies on the d(CpG)-proflavine complex, and molecular mechanics used to obtain a stereocheracally acceptable structure. This has widened grooves compared to standard A- or B- double helices, as well as distinct conformational, roll, twist and tilt features.

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EP - 9015

JO - Nucleic acids research

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A molecular model for proflavine-DNA intercalation

Abstract

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