A multiscale approach for assessing the interactions of environmental and biological systems in a holistic health risk assessment framework

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19 Scopus citations

Abstract

Advances in computing processing power and in availability of environmental and biological data have allowed the development and application of comprehensive modeling systems that utilize a holistic, integrated, approach for assessing the interactions of environmental and biological systems across multiple scales of spatiotemporal extent and biological organization. This approach allows mechanism-based environmental health risk assessments in a person-oriented framework, which accounts for simultaneous exposures to contaminants from multiple media, routes, and pathways. The conceptual basis and example applications of the Modeling ENvironment for TOtal Risk (MENTOR), and the DOse-Response Information ANalysis system (DORIAN) are presented.

Original languageEnglish (US)
Pages (from-to)3-21
Number of pages19
JournalWater, Air, and Soil Pollution: Focus
Volume8
Issue number1
DOIs
StatePublished - Feb 1 2008

All Science Journal Classification (ASJC) codes

  • Water Science and Technology
  • Pollution
  • Earth-Surface Processes
  • Earth and Planetary Sciences(all)

Keywords

  • Comprehensive modeling systems
  • DORIAN
  • Environmental health
  • Exposures to mixtures
  • MENTOR
  • Risk assessments

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