A mutant of Mycobacterium smegmatis defective in dipeptide transport

Achal Bhatt; Renee Green; Roswell Coles; Michael Condon; Nancy D. Connell

doi:10.1128/jb.180.24.6773-6775.1998

A mutant of Mycobacterium smegmatis defective in dipeptide transport

Achal Bhatt, Renee Green, Roswell Coles, Michael Condon, Nancy D. Connell

New Jersey Medical School (NJMS), Medicine, Division of Infectious Disease

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine (β-alanyl-L-histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on β-Ala and/or L- His were similar in the mutant and the wild type. However, the mutant showed significant impairment in the uptake of camosine. This study is the first description of a peptide utilization mutant of a mycobacterium.

Original language	English (US)
Pages (from-to)	6773-6775
Number of pages	3
Journal	Journal of bacteriology
Volume	180
Issue number	24
DOIs	https://doi.org/10.1128/jb.180.24.6773-6775.1998
State	Published - Dec 1998

All Science Journal Classification (ASJC) codes

Microbiology
Molecular Biology

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10.1128/jb.180.24.6773-6775.1998

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AU - Bhatt, Achal

AU - Green, Renee

AU - Coles, Roswell

AU - Condon, Michael

AU - Connell, Nancy D.

PY - 1998/12

Y1 - 1998/12

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AB - A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine (β-alanyl-L-histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on β-Ala and/or L- His were similar in the mutant and the wild type. However, the mutant showed significant impairment in the uptake of camosine. This study is the first description of a peptide utilization mutant of a mycobacterium.

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A mutant of Mycobacterium smegmatis defective in dipeptide transport

Abstract

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