A negative correlation between the induction of long-term potentiation and activation of immediate early genes

Steven S. Schreiber, Stephen Maren, Georges Tocco, Tracey Jo Shors, Richard F. Thompson

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

In the present study we examined the relationship between the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats and activation of immediate early genes (IEGs; c-fos and zif/268 using several different high-frequency stimulation paradigms. Stimulation parameters that effectively induced LTP were not associated with IEG activation. Conversely, stimulation parameters that failed to induced LTP consistently resulted in IEG activation. These results suggest that there is a negative correlation between IEG activation and LTP, and that activation of IEGs is neither necessary nor sufficient for the induction of LTP.

Original languageEnglish (US)
Pages (from-to)89-91
Number of pages3
JournalMolecular Brain Research
Volume11
Issue number1
DOIs
StatePublished - Aug 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Keywords

  • Dentate gyrus
  • Immediate early gene
  • Long-term potentiation
  • c-fos
  • zif/268

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