A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB)

Huarong Huang, Ting Liu, Xiaoen Wu, Junxi Guo, Xiong Lan, Qin Zhu, Xi Zheng, Kun Zhang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

One new chromone derivative, (2ʹS*)-2-(2ʹ-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2.00 ± 0.02 μM. Compound 2 and 3 possessed significant inhibitory activity against α-glucosidase with IC50 values of 33.55 ± 0.63 and 95.81 ± 1.12 μM, respectively.

Original languageEnglish (US)
Pages (from-to)2593-2598
Number of pages6
JournalNatural Product Research
Volume31
Issue number22
DOIs
StatePublished - Nov 17 2017

Fingerprint

Chromones
glucosidases
Penicillium
Fungi
Bacillus subtilis
inhibitory concentration 50
Glucosidases
Derivatives
fungi
Bacilli
Inhibitory Concentration 50

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Keywords

  • Chromone derivative
  • Penicillium sp
  • antibacterial activity
  • mangrove-derived fungus
  • α-glucosidase inhibition

Cite this

Huang, Huarong ; Liu, Ting ; Wu, Xiaoen ; Guo, Junxi ; Lan, Xiong ; Zhu, Qin ; Zheng, Xi ; Zhang, Kun. / A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB). In: Natural Product Research. 2017 ; Vol. 31, No. 22. pp. 2593-2598.
@article{45bcb0773c644b97a0ee0a161ebc50f7,
title = "A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB)",
abstract = "One new chromone derivative, (2ʹS*)-2-(2ʹ-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2.00 ± 0.02 μM. Compound 2 and 3 possessed significant inhibitory activity against α-glucosidase with IC50 values of 33.55 ± 0.63 and 95.81 ± 1.12 μM, respectively.",
keywords = "Chromone derivative, Penicillium sp, antibacterial activity, mangrove-derived fungus, α-glucosidase inhibition",
author = "Huarong Huang and Ting Liu and Xiaoen Wu and Junxi Guo and Xiong Lan and Qin Zhu and Xi Zheng and Kun Zhang",
year = "2017",
month = "11",
day = "17",
doi = "10.1080/14786419.2017.1283498",
language = "English (US)",
volume = "31",
pages = "2593--2598",
journal = "Natural Product Research",
issn = "1478-6419",
publisher = "Taylor and Francis Ltd.",
number = "22",

}

A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB). / Huang, Huarong; Liu, Ting; Wu, Xiaoen; Guo, Junxi; Lan, Xiong; Zhu, Qin; Zheng, Xi; Zhang, Kun.

In: Natural Product Research, Vol. 31, No. 22, 17.11.2017, p. 2593-2598.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB)

AU - Huang, Huarong

AU - Liu, Ting

AU - Wu, Xiaoen

AU - Guo, Junxi

AU - Lan, Xiong

AU - Zhu, Qin

AU - Zheng, Xi

AU - Zhang, Kun

PY - 2017/11/17

Y1 - 2017/11/17

N2 - One new chromone derivative, (2ʹS*)-2-(2ʹ-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2.00 ± 0.02 μM. Compound 2 and 3 possessed significant inhibitory activity against α-glucosidase with IC50 values of 33.55 ± 0.63 and 95.81 ± 1.12 μM, respectively.

AB - One new chromone derivative, (2ʹS*)-2-(2ʹ-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2.00 ± 0.02 μM. Compound 2 and 3 possessed significant inhibitory activity against α-glucosidase with IC50 values of 33.55 ± 0.63 and 95.81 ± 1.12 μM, respectively.

KW - Chromone derivative

KW - Penicillium sp

KW - antibacterial activity

KW - mangrove-derived fungus

KW - α-glucosidase inhibition

UR - http://www.scopus.com/inward/record.url?scp=85011575294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011575294&partnerID=8YFLogxK

U2 - 10.1080/14786419.2017.1283498

DO - 10.1080/14786419.2017.1283498

M3 - Article

C2 - 28147702

AN - SCOPUS:85011575294

VL - 31

SP - 2593

EP - 2598

JO - Natural Product Research

JF - Natural Product Research

SN - 1478-6419

IS - 22

ER -