A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB)

Huarong Huang, Ting Liu, Xiaoen Wu, Junxi Guo, Xiong Lan, Qin Zhu, Xi Zheng, Kun Zhang

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Abstract

One new chromone derivative, (2ʹS*)-2-(2ʹ-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2.00 ± 0.02 μM. Compound 2 and 3 possessed significant inhibitory activity against α-glucosidase with IC50 values of 33.55 ± 0.63 and 95.81 ± 1.12 μM, respectively.

Original languageEnglish (US)
Pages (from-to)2593-2598
Number of pages6
JournalNatural Product Research
Volume31
Issue number22
DOIs
StatePublished - Nov 17 2017

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Keywords

  • Chromone derivative
  • Penicillium sp
  • antibacterial activity
  • mangrove-derived fungus
  • α-glucosidase inhibition

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