[Chemical Equation Presented] While β-ketoesters are useful Michael donors, they were previously ineffective in Michael-Michael cascade reactions using αβ-unsaturated aldehydes in conjunction with diphenylprolinol silyl ether organocatalysts. However, through rational modification of substrates and manipulation of the catalytic cycle, we developed an efficient Michael-Michael cascade reaction using β-ketoesters of type 9. In this transformation, highly substituted fused carbocycles are generated In a single step In up to 87% yield and 99% ee.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Dec 17 2009|
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry