A new strategy for the protection of deoxyguanosine during oligonucleotide synthesis

B. L. Gaffney, R. A. Jones

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

The protection of the 6-oxo group of deoxyguanosine with the 2-trimethylsilylethyl (2), phenylthioethyl (3), 4-nitrophenylthioethyl (4), 4-nintrophenethyl (5), and cyanoethyl (6) groups is described. Each protecting group is introduced in good yield and is cleaved under mild conditions. Compatibility with the various approaches to oligonucleotide synthesis is discussed.

Original languageEnglish (US)
Pages (from-to)2257-2260
Number of pages4
JournalTetrahedron Letters
Volume23
Issue number22
DOIs
StatePublished - 1982

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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