The protection of the 6-oxo group of deoxyguanosine with the 2-trimethylsilylethyl (2), phenylthioethyl (3), 4-nitrophenylthioethyl (4), 4-nintrophenethyl (5), and cyanoethyl (6) groups is described. Each protecting group is introduced in good yield and is cleaved under mild conditions. Compatibility with the various approaches to oligonucleotide synthesis is discussed.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry