Abstract

Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking.

Original languageEnglish (US)
Pages (from-to)177-179
Number of pages3
JournalCell
Volume132
Issue number2
DOIs
StatePublished - Jan 25 2008

Fingerprint

Genes
Glucosyltransferases
Epidermal Growth Factor
Sugars
Serine
Drosophila
Glucose
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Irvine, Kenneth. / A Notch Sweeter. In: Cell. 2008 ; Vol. 132, No. 2. pp. 177-179.
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A Notch Sweeter. / Irvine, Kenneth.

In: Cell, Vol. 132, No. 2, 25.01.2008, p. 177-179.

Research output: Contribution to journalShort survey

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