A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance

Boominathan Amutha, Donna M. Gordon, Yajuan Gu, Debkumar Pain

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

In Saccharomyces cerevisiae, two mitochondrial inner-membrane proteins play critical roles in organellar morphology. One is a dynamin-related GTPase, Mgm1p, which participates in mitochondrial fusion. Another is Tim11p, which is required for oligomeric assembly of F1Fo-ATP synthase, which generates ATP through oxidative phosphorylation. Our data bring these findings together and define a novel role for Mgm1p in the formation and maintenance of mitochondrial cristae. We show that Mgm1p serves as an upstream regulator of Tim11p protein stability, ATP synthase assembly, cristae morphology and cytochrome c storage within cristae.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalBiochemical Journal
Volume381
Issue number1
DOIs
StatePublished - Jul 1 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Keywords

  • ATP synthase
  • Cytochrome c
  • Mgm1p
  • Mitochondria
  • Rhomboid-like protease
  • Tim11p

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