Abstract
The neamine part of the aminoglycoside antibiotic neomycin B was conjugated to a 16 mer peptide nucleic acid (PNA) targeting HIV-1 TAR RNA. Attachment of the neamine core allows cellular uptake of the PNA and results in potent inhibition of HIV-1 replication. The polycationic neamine moiety imparts greater solubility to the PNA and also confers a unique RNA cleavage property to the conjugate which is specific to its target site and functional at physiological concentrations of Mg2+. These properties suggest a potential therapeutic application for this class of compounds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4806-4809 |
| Number of pages | 4 |
| Journal | Journal of medicinal chemistry |
| Volume | 47 |
| Issue number | 20 |
| DOIs | |
| State | Published - Sep 23 2004 |
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery
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Cite this
Riguet, E., Tripathi, S., Chaubey, B., Désiré, J., Pandey, V. N., & Décout, J. L. (2004). A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication. Journal of medicinal chemistry, 47(20), 4806-4809. https://doi.org/10.1021/jm049642d