A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication

Emmanuel Riguet, Snehlata Tripathi, Binay Chaubey, Jérôme Désiré, Virendra N. Pandey, Jean Luc Décout

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

The neamine part of the aminoglycoside antibiotic neomycin B was conjugated to a 16 mer peptide nucleic acid (PNA) targeting HIV-1 TAR RNA. Attachment of the neamine core allows cellular uptake of the PNA and results in potent inhibition of HIV-1 replication. The polycationic neamine moiety imparts greater solubility to the PNA and also confers a unique RNA cleavage property to the conjugate which is specific to its target site and functional at physiological concentrations of Mg2+. These properties suggest a potential therapeutic application for this class of compounds.

Original languageEnglish (US)
Pages (from-to)4806-4809
Number of pages4
JournalJournal of medicinal chemistry
Volume47
Issue number20
DOIs
StatePublished - Sep 23 2004

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Fingerprint Dive into the research topics of 'A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication'. Together they form a unique fingerprint.

  • Cite this