Abstract
The neamine part of the aminoglycoside antibiotic neomycin B was conjugated to a 16 mer peptide nucleic acid (PNA) targeting HIV-1 TAR RNA. Attachment of the neamine core allows cellular uptake of the PNA and results in potent inhibition of HIV-1 replication. The polycationic neamine moiety imparts greater solubility to the PNA and also confers a unique RNA cleavage property to the conjugate which is specific to its target site and functional at physiological concentrations of Mg2+. These properties suggest a potential therapeutic application for this class of compounds.
Original language | English (US) |
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Pages (from-to) | 4806-4809 |
Number of pages | 4 |
Journal | Journal of medicinal chemistry |
Volume | 47 |
Issue number | 20 |
DOIs | |
State | Published - Sep 23 2004 |
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery