A peroxide-induced inflammation model for drug testing

Charles Spillert, M. A. Pelosi, L. P. Parmer, E. J. Lazaro

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Peroxide-induced cellular injury is an important mediator of inflammation. Whether the injection of glucose oxidase (GO) with its generation of H2O2 may be utilized as an inflammatory model was studied. Anesthesized mice were injected in the right hind foot with either water or an equal volume of 10 or 100 units/ml GO. The animals were sacrificed at 1.5 or 24 hours post injection and both hind feet amputated and each foot weighed. Difference in weights for each animal's feet was called edema index (EI). GO produced significant increases in weight. The use of GO to produce inflammation may be useful in testing potential peroxide quenching agents.

Original languageEnglish (US)
Pages (from-to)297-298
Number of pages2
JournalAgents and Actions
Volume21
Issue number3-4
DOIs
StatePublished - Aug 1 1987

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology (medical)

Cite this