A Phe389Leu substitution in ErgA confers terbinafine resistance in Aspergillus fumigatus

E. M.F. Rocha, R. E. Gardiner, S. Park, N. M. Martinez-Rossi, D. S. Perlin

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

Original languageEnglish (US)
Pages (from-to)2533-2536
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number7
DOIs
StatePublished - Jul 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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