A Phe389Leu substitution in ErgA confers terbinafine resistance in Aspergillus fumigatus

E. M.F. Rocha; R. E. Gardiner; S. Park; N. M. Martinez-Rossi; D. S. Perlin

doi:10.1128/AAC.00187-06

A Phe389Leu substitution in ErgA confers terbinafine resistance in Aspergillus fumigatus

E. M.F. Rocha, R. E. Gardiner, S. Park, N. M. Martinez-Rossi, D. S. Perlin

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

Original language	English (US)
Pages (from-to)	2533-2536
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00187-06
State	Published - Jul 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold.",

author = "Rocha, {E. M.F.} and Gardiner, {R. E.} and S. Park and Martinez-Rossi, {N. M.} and Perlin, {D. S.}",

year = "2006",

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AU - Gardiner, R. E.

AU - Park, S.

AU - Martinez-Rossi, N. M.

AU - Perlin, D. S.

PY - 2006/7

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N2 - Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

AB - Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

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ER -

A Phe389Leu substitution in ErgA confers terbinafine resistance in Aspergillus fumigatus

Abstract

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