A potent excitatory input to the nucleus locus coeruleus from the ventrolateral medulla

Matthew Ennis, Gary Aston-Jones

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Our recent anatomic experiments reveal major innervation of the nucleus locus coeruleus (LC) from the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla. In the present studies, low intensity, single pulse electrical stimulation of the PGi synaptically activated most LC neurons examined (69%), while a smaller percentage of LC cells (20%) exhibited pure inhibitory responses. Pharmacologic experiments suggest that the excitatory response may be mediated by an amino acid transmitter.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalNeuroscience Letters
Volume71
Issue number3
DOIs
StatePublished - Nov 21 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Afferent
  • Electrical stimulation
  • Locus coeruleus
  • Norepinephrine
  • Paragigantocellularis
  • Unit recording
  • Ventrolateral medulla

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