A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex

Kyung Sik Song, Ilya Raskin

Research output: Contribution to journalArticle

37 Scopus citations


A new benzofuran dimer, 5,6,5′,6′-tetrahydroxy[3,3′]bibenzofuranyl-2,2′- dicarboxylic acid dimethyl ester (kynapcin-24), was isolated from Polyozellus multiflex and shown to noncompetitively inhibit prolyl endopeptidase (PEP), with an IC50 value of 1.14 μM. Kynapcin-24 was less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.

Original languageEnglish (US)
Pages (from-to)76-78
Number of pages3
JournalJournal of Natural Products
Issue number1
StatePublished - Feb 12 2002

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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