A radiation hybrid map spanning the entire human X Chromosome integrating YACs, genes, and STS markers

J. Kumlien; A. Grigoriev; H. Roest Crollius; M. Ross; P. N. Goodfellow; H. Lehrach

doi:10.1007/s003359900227

A radiation hybrid map spanning the entire human X Chromosome integrating YACs, genes, and STS markers

J. Kumlien, A. Grigoriev, H. Roest Crollius, M. Ross, P. N. Goodfellow, H. Lehrach

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We present a radiation hybrid (RH) map of human Chromosome (Chr) X, using 50 markers on 72 radiation hybrids. The markers, obtained from the consensus map, form a grid spanning the entire chromosome. To check the RH map, the marker order was determined by analysis of presence or absence of retained human DNA fragments in the RHs: the comparison with the consensus showed a similar order. Any STSs, microsatellites, genes, and clones can be positioned and ordered relative to the marker grid. This approach integrates genetic, physical, and large-scale clone mapping and is used to link YAC contigs containing data from various experimental sources.

Original language	English (US)
Pages (from-to)	758-766
Number of pages	9
Journal	Mammalian Genome
Volume	7
Issue number	10
DOIs	https://doi.org/10.1007/s003359900227
State	Published - Jan 1 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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10.1007/s003359900227

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abstract = "We present a radiation hybrid (RH) map of human Chromosome (Chr) X, using 50 markers on 72 radiation hybrids. The markers, obtained from the consensus map, form a grid spanning the entire chromosome. To check the RH map, the marker order was determined by analysis of presence or absence of retained human DNA fragments in the RHs: the comparison with the consensus showed a similar order. Any STSs, microsatellites, genes, and clones can be positioned and ordered relative to the marker grid. This approach integrates genetic, physical, and large-scale clone mapping and is used to link YAC contigs containing data from various experimental sources.",

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AU - Kumlien, J.

AU - Grigoriev, A.

AU - Roest Crollius, H.

AU - Ross, M.

AU - Goodfellow, P. N.

AU - Lehrach, H.

PY - 1996/1/1

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