A randomized controlled trial of mindfulness-based stress reduction for women with early-stage breast cancer receiving radiotherapy

Virginia P. Henderson, Ann O. Massion, Lynn Clemow, Thomas G. Hurley, Susan Druker, James R. Hébert

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Purpose. To testthe relative effectiveness of a mindfulness-based stress reduction program (MBSR) compared with a nutrition education intervention (NEP) and usual care (UC) in women with newly diagnosed early-stage breast cancer (BrCA)undergoing radiotherapy. Methods. Datawere available from a randomized controlled trialof 172 women, 20 to 65 years old, with stage I or II BrCA. Data from women completing the 8-week MBSR program plus 3 additional sessions focuses on special needs associated with BrCA were compared to women receiving attention control NEP and UC. Follow-up was performed at 3 post-intervention points: 4 months, and 1 and 2 years. Standardized, validated self-administered questionnaires were used to assess psychosocial variables. Descriptive analyses compared women by randomization assignment. Regression analyses, incorporating both intention-to-treat and post hoc multivariable approaches, were used to control for potential confounding variables. Results. A subset of 120 women underwent radiotherapy; 77 completed treatment prior to the study, and 40 had radiotherapy during the MBSR intervention. Women who actively received radiotherapy (art) while participating in the MBSR intervention (MBSR-art) experienced a significant (P <.05) improvement in 16 psychosocial variables compared with the NEP-art, UC-art, or both at 4 months. These included health-related, BrCA-specific quality of life and psychosocial coping, which were the primary outcomes, and secondary measures, including meaningfulness, helplessness, cognitive avoidance, depression, paranoid ideation, hostility, anxiety, global severity, anxious preoccupation, and emotional control. Conclusions. MBSR appears to facilitate psychosocial adjustment in BrCA patients receiving radiotherapy, suggesting applicability for MBSR as adjunctive therapy in oncological practice.

Original languageEnglish (US)
Pages (from-to)404-413
Number of pages10
JournalIntegrative Cancer Therapies
Volume12
Issue number5
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Complementary and alternative medicine

Keywords

  • breast cancer
  • mindfulness-based stress reduction program
  • psychosocial intervention
  • quality of life
  • radiation therapy
  • radiotherapy

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