A ribosomal perspective on the mechanism of selenocysteine incorporation

Kelvin Caban, Paul R. Copeland

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Selenocysteine (Sec) is cotranslationally inserted into polypeptides during the elongation phase of protein synthesis in response to specific UGA codons. As UGA normally signals translation termination, the Sec incorporation complex is required to modify the canonical translation machinery. Thus, a thorough understanding of the Sec incorporation mechanism necessitates careful consideration of the intricacies of general translation, specifically during the elongation phase. Here, we consider the current body of evidence that supports a key role for the ribosome in regulating the process of Sec incorporation.

Original languageEnglish (US)
Title of host publicationSelenium
Subtitle of host publicationIts Molecular Biology and Role in Human Health
PublisherSpringer New York
Pages61-72
Number of pages12
Volume9781461410256
ISBN (Electronic)9781461410256
ISBN (Print)146141024X, 9781461410249
DOIs
StatePublished - Jun 1 2012

Fingerprint

Selenocysteine
Elongation
Terminator Codon
Ribosomes
Machinery
Peptides
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Caban, K., & Copeland, P. R. (2012). A ribosomal perspective on the mechanism of selenocysteine incorporation. In Selenium: Its Molecular Biology and Role in Human Health (Vol. 9781461410256, pp. 61-72). Springer New York. https://doi.org/10.1007/978-1-4614-1025-6_5
Caban, Kelvin ; Copeland, Paul R. / A ribosomal perspective on the mechanism of selenocysteine incorporation. Selenium: Its Molecular Biology and Role in Human Health. Vol. 9781461410256 Springer New York, 2012. pp. 61-72
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Caban, K & Copeland, PR 2012, A ribosomal perspective on the mechanism of selenocysteine incorporation. in Selenium: Its Molecular Biology and Role in Human Health. vol. 9781461410256, Springer New York, pp. 61-72. https://doi.org/10.1007/978-1-4614-1025-6_5

A ribosomal perspective on the mechanism of selenocysteine incorporation. / Caban, Kelvin; Copeland, Paul R.

Selenium: Its Molecular Biology and Role in Human Health. Vol. 9781461410256 Springer New York, 2012. p. 61-72.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Caban K, Copeland PR. A ribosomal perspective on the mechanism of selenocysteine incorporation. In Selenium: Its Molecular Biology and Role in Human Health. Vol. 9781461410256. Springer New York. 2012. p. 61-72 https://doi.org/10.1007/978-1-4614-1025-6_5