Abstract
An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4174-4176 |
| Number of pages | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 51 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2007 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Cite this
Rocha, E. M. F., Garcia-Effron, G., Park, S., & Perlin, D. S. (2007). A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Antimicrobial agents and chemotherapy, 51(11), 4174-4176. https://doi.org/10.1128/AAC.00917-07