TY - JOUR
T1 - A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus
AU - Rocha, Eleusa Maria F.
AU - Garcia-Effron, Guillermo
AU - Park, Steven
AU - Perlin, David S.
PY - 2007/11
Y1 - 2007/11
N2 - An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.
AB - An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.
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U2 - 10.1128/AAC.00917-07
DO - 10.1128/AAC.00917-07
M3 - Article
C2 - 17724146
AN - SCOPUS:35848964834
VL - 51
SP - 4174
EP - 4176
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 11
ER -