A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus

E. M F Rocha, Guillermo Garcia-Effron, Steven Park, David S. Perlin

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Abstract

An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.

Original languageEnglish (US)
Pages (from-to)4174-4176
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number11
DOIs
StatePublished - Nov 1 2007

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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