A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus

E. M F Rocha, Guillermo Garcia-Effron, Steven Park, David S. Perlin

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.

Original languageEnglish (US)
Pages (from-to)4174-4176
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number11
DOIs
StatePublished - Nov 1 2007

Fingerprint

Echinocandins
Aspergillus fumigatus
Pharmaceutical Preparations
Candida
Fungi
Mutation

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Rocha, E. M F ; Garcia-Effron, Guillermo ; Park, Steven ; Perlin, David S. / A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. In: Antimicrobial agents and chemotherapy. 2007 ; Vol. 51, No. 11. pp. 4174-4176.
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A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. / Rocha, E. M F; Garcia-Effron, Guillermo; Park, Steven; Perlin, David S.

In: Antimicrobial agents and chemotherapy, Vol. 51, No. 11, 01.11.2007, p. 4174-4176.

Research output: Contribution to journalArticle

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