A simple one-pot multicomponent synthesis of an octahedral nanocontainer molecule

Xuejun Liu, Ralf Warmuth

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A nearly quantitative 18-component synthesis of a nanocontainer, which is built up from six bowl-shaped cavitands that are connected together with 12 -CH=N-CH2CH2-N=CH- linkers, and its subsequent reduction are described. This nanocontainer has an estimated cavity volume of 1,700 Å3, large enough to encapsulate several smaller guest molecules or a small-sized biomacromolecule. Potential uses of this nanocontainer and of water-soluble derivatives are in drug delivery, wastewater detoxification, separation technology and as molecular reactor for controlled oligomerizations. Typically, the four-step synthesis of the cavitand building block and the subsequent multicomponent synthesis of the nanocontainer, including its purification, can be accomplished in about 4 weeks.

Original languageEnglish (US)
Pages (from-to)1288-1296
Number of pages9
JournalNature Protocols
Issue number5
StatePublished - May 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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