A speculation on the origin of protein synthesis

F. H.C. Crick, S. Brenner, A. Klug, G. Pieczenik

Research output: Contribution to journalArticle

216 Scopus citations


It is suggested that protein synthesis may have begun without even a primitive ribosome if the primitive tRNA could take up two configurations and could bind to the messenger RNA with five base-pairs instead of the present three. This idea would impose base sequence restriction on the early messages and on the early genetic code such that the first four amino acids coded were glycine, serine, aspartic acid and aspargine. A possible mechanism is suggested for the polymerization of the early message.

Original languageEnglish (US)
Pages (from-to)389-397
Number of pages9
JournalOrigins of Life
Issue number4
StatePublished - Dec 1 1976
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Environmental Science(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Earth and Planetary Sciences(all)

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