A step closer to complete chemical reprogramming for generating iPS cells

Aniruddh Solanki, Ki Bum Lee

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

The chemical approach: To overcome the problems involved in using viral vectors and transgenes to generate induced pluripotent stem cells, Ichida et al., have discovered a small molecule, RepSox, that successfully replaces the transcription factor Sox2 in reprogramming somatic cells into iPSCs by inhibiting transforming growth factor-β signaling. Figure Equotion Present

Original languageEnglish (US)
Pages (from-to)755-757
Number of pages3
JournalChemBioChem
Volume11
Issue number6
DOIs
StatePublished - Apr 12 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Keywords

  • Induced pluripotent stem cells
  • Small molecules
  • Sox2
  • Transcription factors
  • Transgenes

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