A study of heat and radiation response of a malignant, melanin-producing cell line derived from C3H 10T1/2 cells transformed in culture by radiation

G. P. Raaphorst, J. Vadasz, E. I. Azzam

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The mouse C3H 10TI/2 cell line was transformed to the malignant state using ionizing radiation. One of the transformed lines (R25) that was isolated, displayed some properties similar to malignant melanoma cells. The cells became dark and pigmented after prolonged time in culture and this cell line produced tumors in C3H mice. The radiation survival curve of R25 had a large shoulder which was also observed for human melanoma cell lines. R25 was more resistant to heating at 45.0°C than the normal cell line. Heating at 45.0°C before irradiation resulted in a reducion of the survival curve shoulder. The heat and radiation sensitivity of R25 did not appear to be related to the melanin content of these cells.

Original languageEnglish (US)
Pages (from-to)2151-2155
Number of pages5
JournalInternational journal of radiation oncology, biology, physics
Volume12
Issue number12
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Keywords

  • Hyperthermia
  • Melanoma
  • Radiation
  • Transformation

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