A study of HLA antigens and haplotypes in a population of Caucasians with acute non-lymphocytic leukemia

Peter A. Daly; Richard Simon; Charles A. Schiffer; Joseph Aisner; Paul I. Terasaki; Peter H. Wiernik

doi:10.1016/0145-2126(79)90065-1

A study of HLA antigens and haplotypes in a population of Caucasians with acute non-lymphocytic leukemia

Peter A. Daly, Richard Simon, Charles A. Schiffer, Joseph Aisner, Paul I. Terasaki, Peter H. Wiernik

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9 Scopus citations

Abstract

An analysis was performed of the HLA types of 136 Caucasian patients with acute nonlymphocytic leukemia (ANLL). Haplotypes were determined from family typing data for 101 of these patients. No increased prevalence of any A or B locus antigen was found in patients with ANLL when compared to a matched control group. The distribution of antigens in the patients did not differ from their siblings and haplotype distribution did not differ from controls. Long-term survival (>2y) was not associated with any particular HLA antigen or haplotype. The number of homozygotes in the study group was not increased. In this group of patients with ANLL no association could be found between HLA antigens and the development or subsequent course of the disease.

Original language	English (US)
Pages (from-to)	75-82
Number of pages	8
Journal	Leukemia Research
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0145-2126(79)90065-1
State	Published - 1979

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

Keywords

Acute leukemia
HLA antigens

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10.1016/0145-2126(79)90065-1

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title = "A study of HLA antigens and haplotypes in a population of Caucasians with acute non-lymphocytic leukemia",

abstract = "An analysis was performed of the HLA types of 136 Caucasian patients with acute nonlymphocytic leukemia (ANLL). Haplotypes were determined from family typing data for 101 of these patients. No increased prevalence of any A or B locus antigen was found in patients with ANLL when compared to a matched control group. The distribution of antigens in the patients did not differ from their siblings and haplotype distribution did not differ from controls. Long-term survival (>2y) was not associated with any particular HLA antigen or haplotype. The number of homozygotes in the study group was not increased. In this group of patients with ANLL no association could be found between HLA antigens and the development or subsequent course of the disease.",

keywords = "Acute leukemia, HLA antigens",

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T1 - A study of HLA antigens and haplotypes in a population of Caucasians with acute non-lymphocytic leukemia

AU - Daly, Peter A.

AU - Simon, Richard

AU - Schiffer, Charles A.

AU - Aisner, Joseph

AU - Terasaki, Paul I.

AU - Wiernik, Peter H.

PY - 1979

Y1 - 1979

N2 - An analysis was performed of the HLA types of 136 Caucasian patients with acute nonlymphocytic leukemia (ANLL). Haplotypes were determined from family typing data for 101 of these patients. No increased prevalence of any A or B locus antigen was found in patients with ANLL when compared to a matched control group. The distribution of antigens in the patients did not differ from their siblings and haplotype distribution did not differ from controls. Long-term survival (>2y) was not associated with any particular HLA antigen or haplotype. The number of homozygotes in the study group was not increased. In this group of patients with ANLL no association could be found between HLA antigens and the development or subsequent course of the disease.

AB - An analysis was performed of the HLA types of 136 Caucasian patients with acute nonlymphocytic leukemia (ANLL). Haplotypes were determined from family typing data for 101 of these patients. No increased prevalence of any A or B locus antigen was found in patients with ANLL when compared to a matched control group. The distribution of antigens in the patients did not differ from their siblings and haplotype distribution did not differ from controls. Long-term survival (>2y) was not associated with any particular HLA antigen or haplotype. The number of homozygotes in the study group was not increased. In this group of patients with ANLL no association could be found between HLA antigens and the development or subsequent course of the disease.

KW - Acute leukemia

KW - HLA antigens

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A study of HLA antigens and haplotypes in a population of Caucasians with acute non-lymphocytic leukemia

Abstract

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