A systems theory with retroactivity: Application to transcriptional modules

D. Del Vecchio, A. J. Ninfa, E. D. Sontag

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations


In standard control systems theory, a system is modeled as an input/output (I/O) module with internal dynamics. This implicitly assumes that the dynamics of a module do not change when the module is connected to other components. However, such an assumption is not realistic in a wide number of electrical, hydraulic, mechanical, and biological systems. We thus propose a new model that incorporates signals that travel from downstream to upstream, which we broadly call retroactivity. We quantify such a retroactivity in transcriptional components and show how to attenuate its effect by the design of insulation devices.

Original languageEnglish (US)
Title of host publication2008 American Control Conference, ACC
Number of pages6
StatePublished - 2008
Event2008 American Control Conference, ACC - Seattle, WA, United States
Duration: Jun 11 2008Jun 13 2008

Publication series

NameProceedings of the American Control Conference
ISSN (Print)0743-1619


Other2008 American Control Conference, ACC
Country/TerritoryUnited States
CitySeattle, WA

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering


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