TY - GEN
T1 - A systems theory with retroactivity
T2 - 2008 American Control Conference, ACC
AU - Del Vecchio, D.
AU - Ninfa, A. J.
AU - Sontag, E. D.
PY - 2008
Y1 - 2008
N2 - In standard control systems theory, a system is modeled as an input/output (I/O) module with internal dynamics. This implicitly assumes that the dynamics of a module do not change when the module is connected to other components. However, such an assumption is not realistic in a wide number of electrical, hydraulic, mechanical, and biological systems. We thus propose a new model that incorporates signals that travel from downstream to upstream, which we broadly call retroactivity. We quantify such a retroactivity in transcriptional components and show how to attenuate its effect by the design of insulation devices.
AB - In standard control systems theory, a system is modeled as an input/output (I/O) module with internal dynamics. This implicitly assumes that the dynamics of a module do not change when the module is connected to other components. However, such an assumption is not realistic in a wide number of electrical, hydraulic, mechanical, and biological systems. We thus propose a new model that incorporates signals that travel from downstream to upstream, which we broadly call retroactivity. We quantify such a retroactivity in transcriptional components and show how to attenuate its effect by the design of insulation devices.
UR - http://www.scopus.com/inward/record.url?scp=52449134943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52449134943&partnerID=8YFLogxK
U2 - 10.1109/ACC.2008.4586683
DO - 10.1109/ACC.2008.4586683
M3 - Conference contribution
AN - SCOPUS:52449134943
SN - 9781424420797
T3 - Proceedings of the American Control Conference
SP - 1368
EP - 1373
BT - 2008 American Control Conference, ACC
Y2 - 11 June 2008 through 13 June 2008
ER -