A technique for microiontophoretic study of single neurons in the freely moving rat

Mark O. West; Donald J. Woodward

doi:10.1016/0165-0270(84)90036-0

A technique for microiontophoretic study of single neurons in the freely moving rat

Mark O. West, Donald J. Woodward

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

An adaptation of a miniature microdrive allows unit recording and microiontophoresis in freely moving rats. Multibarrel glass micropipets are inserted into the detachable microdrive daily, and advanced manually into superficial or deep brain structures. The demonstration of stability in recording neuronal responses to iontophoretically applied drugs suggests that this technique will be useful in studying drug actions on single neurons across a wide range of conscious behaviors.

Original language	English (US)
Pages (from-to)	179-186
Number of pages	8
Journal	Journal of Neuroscience Methods
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0165-0270(84)90036-0
State	Published - Aug 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

behavior, animal neurophysiology
electrophysiology
iontophoresis
microdrive
neural transmission
neuroregulators

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10.1016/0165-0270(84)90036-0

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title = "A technique for microiontophoretic study of single neurons in the freely moving rat",

abstract = "An adaptation of a miniature microdrive allows unit recording and microiontophoresis in freely moving rats. Multibarrel glass micropipets are inserted into the detachable microdrive daily, and advanced manually into superficial or deep brain structures. The demonstration of stability in recording neuronal responses to iontophoretically applied drugs suggests that this technique will be useful in studying drug actions on single neurons across a wide range of conscious behaviors.",

keywords = "behavior, animal neurophysiology, electrophysiology, iontophoresis, microdrive, neural transmission, neuroregulators",

author = "West, {Mark O.} and Woodward, {Donald J.}",

note = "Funding Information: This research was supported by NIDA 02338, NIAAA 03901, and the Biological Humanics Foundation. The authors wish to thank Annette Brown for typing the manuscript.",

year = "1984",

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doi = "10.1016/0165-0270(84)90036-0",

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T1 - A technique for microiontophoretic study of single neurons in the freely moving rat

AU - West, Mark O.

AU - Woodward, Donald J.

N1 - Funding Information: This research was supported by NIDA 02338, NIAAA 03901, and the Biological Humanics Foundation. The authors wish to thank Annette Brown for typing the manuscript.

PY - 1984/8

Y1 - 1984/8

N2 - An adaptation of a miniature microdrive allows unit recording and microiontophoresis in freely moving rats. Multibarrel glass micropipets are inserted into the detachable microdrive daily, and advanced manually into superficial or deep brain structures. The demonstration of stability in recording neuronal responses to iontophoretically applied drugs suggests that this technique will be useful in studying drug actions on single neurons across a wide range of conscious behaviors.

AB - An adaptation of a miniature microdrive allows unit recording and microiontophoresis in freely moving rats. Multibarrel glass micropipets are inserted into the detachable microdrive daily, and advanced manually into superficial or deep brain structures. The demonstration of stability in recording neuronal responses to iontophoretically applied drugs suggests that this technique will be useful in studying drug actions on single neurons across a wide range of conscious behaviors.

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KW - electrophysiology

KW - iontophoresis

KW - microdrive

KW - neural transmission

KW - neuroregulators

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ER -

A technique for microiontophoretic study of single neurons in the freely moving rat

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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