A three-step entry to the aspirochlorine family of antifungal agents

Zhicai Wu, Lawrence J. Williams, Samuel J. Danishefsky

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The quest for superior antifungal agents will be aided by the unprecedented sulfur migration of an epidithioketopiperazine (EDKP) in a highly stereoselective manner and in high yield. The rearrangement provides a short route to compounds in the same family as aspirochlorine (1), a potent inhibitor of fungal protein synthesis. In this family one of the dithio sulfur atoms is anchored to a dihydrobenzofuran ring that is spiro fused to the piperazine ring.

Original languageEnglish (US)
Pages (from-to)3866-3868
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number21
StatePublished - Nov 3 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)


  • Antifungal agents
  • Natural products
  • Rearrangements
  • Sulfur heterocycles


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