A transcriptional co-repressor that interacts with nuclear hormone receptors

J. Don Chen, Ronald M. Evans

Research output: Contribution to journalArticlepeer-review

1669 Scopus citations

Abstract

TRANSCRIPTIONAL silencing mediated by nuclear receptors is important in development, differentiation and oncogenesis1-3. The mechanism underlying this effect is unknown but is one key to understanding the molecular basis of hormone action. Here we identify a receptor-interacting factor, SMRT, as a silencing mediator (co-repressor) for retinoid and thyroid-hormone receptors. SMRT is a previously undiscovered protein whose association with receptors both in solution and bound to DNA-response elements is destabilized by ligand. The interaction with mutant receptors correlates with their transcriptional silencing activities. In vivo, SMRT functions as a potent co-repressor, and a GAL4 DNA-binding domain fusion of SMRT behaves as a frank represser of a GAL4-dependent reporter. Together, our results identify a new class of cofactors which may be important mediators of hormone action.

Original languageEnglish (US)
Pages (from-to)454-457
Number of pages4
JournalNature
Volume377
Issue number6548
DOIs
StatePublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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