A transdermal review on permeation of drug formulations, modifier compounds and delivery methods

V. Rai; I. Ghosh; S. Bose; S. M.C. Silva; P. Chandra; B. Michniak-Kohn

doi:10.1016/s1773-2247(10)50011-x

A transdermal review on permeation of drug formulations, modifier compounds and delivery methods

V. Rai, I. Ghosh, S. Bose, S. M.C. Silva, P. Chandra, B. Michniak-Kohn

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

This article systematically reviews the status of in vitro and in vivo percutaneous permeation of selected compounds reported in the literature and attempts to relate these permeation data to formulations and biochemical changes occurring in human skin, animal skins and skin equivalents. A substantial portion of the article is dedicated in reviewing the status of commercially available drugs and their delivery methods. Information on permeation modifier compounds and in vivo/in vitro (IVIVC) correlations is also provided in order to obtain a complete picture of the research status in the dermatopharmaceutical field.

Original language	English (US)
Pages (from-to)	75-88
Number of pages	14
Journal	Journal of Drug Delivery Science and Technology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/s1773-2247(10)50011-x
State	Published - 2010

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Keywords

Biochemistry of skin
Enhancers
Flux
Formulation effect
Human skin equivalents
In vivo/in vitro correlation (IVIVC)
Organization for Economic Co-operation and Development (OECD)
Percutaneous drug delivery
Permeation modifiers
Pig skin
Rat skin
Retardants

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10.1016/s1773-2247(10)50011-x

Cite this

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title = "A transdermal review on permeation of drug formulations, modifier compounds and delivery methods",

abstract = "This article systematically reviews the status of in vitro and in vivo percutaneous permeation of selected compounds reported in the literature and attempts to relate these permeation data to formulations and biochemical changes occurring in human skin, animal skins and skin equivalents. A substantial portion of the article is dedicated in reviewing the status of commercially available drugs and their delivery methods. Information on permeation modifier compounds and in vivo/in vitro (IVIVC) correlations is also provided in order to obtain a complete picture of the research status in the dermatopharmaceutical field.",

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AU - Rai, V.

AU - Ghosh, I.

AU - Bose, S.

AU - Silva, S. M.C.

AU - Chandra, P.

AU - Michniak-Kohn, B.

PY - 2010

Y1 - 2010

N2 - This article systematically reviews the status of in vitro and in vivo percutaneous permeation of selected compounds reported in the literature and attempts to relate these permeation data to formulations and biochemical changes occurring in human skin, animal skins and skin equivalents. A substantial portion of the article is dedicated in reviewing the status of commercially available drugs and their delivery methods. Information on permeation modifier compounds and in vivo/in vitro (IVIVC) correlations is also provided in order to obtain a complete picture of the research status in the dermatopharmaceutical field.

AB - This article systematically reviews the status of in vitro and in vivo percutaneous permeation of selected compounds reported in the literature and attempts to relate these permeation data to formulations and biochemical changes occurring in human skin, animal skins and skin equivalents. A substantial portion of the article is dedicated in reviewing the status of commercially available drugs and their delivery methods. Information on permeation modifier compounds and in vivo/in vitro (IVIVC) correlations is also provided in order to obtain a complete picture of the research status in the dermatopharmaceutical field.

KW - Biochemistry of skin

KW - Enhancers

KW - Flux

KW - Formulation effect

KW - Human skin equivalents

KW - In vivo/in vitro correlation (IVIVC)

KW - Organization for Economic Co-operation and Development (OECD)

KW - Percutaneous drug delivery

KW - Permeation modifiers

KW - Pig skin

KW - Rat skin

KW - Retardants

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A transdermal review on permeation of drug formulations, modifier compounds and delivery methods

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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