A transdermal review on permeation of drug formulations, modifier compounds and delivery methods

V. Rai, I. Ghosh, S. Bose, S. M.C. Silva, P. Chandra, B. Michniak-Kohn

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

This article systematically reviews the status of in vitro and in vivo percutaneous permeation of selected compounds reported in the literature and attempts to relate these permeation data to formulations and biochemical changes occurring in human skin, animal skins and skin equivalents. A substantial portion of the article is dedicated in reviewing the status of commercially available drugs and their delivery methods. Information on permeation modifier compounds and in vivo/in vitro (IVIVC) correlations is also provided in order to obtain a complete picture of the research status in the dermatopharmaceutical field.

Original languageEnglish (US)
Pages (from-to)75-88
Number of pages14
JournalJournal of Drug Delivery Science and Technology
Volume20
Issue number2
StatePublished - Jan 1 2010

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Biochemistry of skin
  • Enhancers
  • Flux
  • Formulation effect
  • Human skin equivalents
  • In vivo/in vitro correlation (IVIVC)
  • Organization for Economic Co-operation and Development (OECD)
  • Percutaneous drug delivery
  • Permeation modifiers
  • Pig skin
  • Rat skin
  • Retardants

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