A unifying translational framework to advance treatment research for comorbid PTSD and substance use disorders

Denise A. Hien, Teresa López-Castro, Skye Fitzpatrick, Lesia M. Ruglass, Eric A. Fertuck, Robert Melara

Research output: Contribution to journalReview articlepeer-review

Abstract

We provide a unifying translational framework that can be used to synthesize extant lines of human laboratory research in four neurofunctional domains that underlie the co-occurrence of posttraumatic stress and substance use disorders (PTSD+SUD). We draw upon the Alcohol and Addiction Research Domain Criteria (AARDOC) to include executive functioning, negative emotionality, reward, and added social cognition from the National Institute of Mental Health (NIMH) Research Domain Criteria into our framework. We review research findings across each of the four domains, emphasizing human experimental studies in PTSD, SUD, and PTSD+SUD for each domain. We also discuss the implications of research findings for treatment development by considering new ways of conceptualizing risk factors and outcomes at the level of the individual patient, which will enhance treatment matching and advance innovations in intervention.

Original languageEnglish (US)
Pages (from-to)779-794
Number of pages16
JournalNeuroscience and Biobehavioral Reviews
Volume127
DOIs
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Keywords

  • Executive functioning
  • Negative emotionality
  • PTSD
  • PTSD comorbidity
  • PTSD+SUD
  • Reward salience
  • Social cognition
  • Substance use disorders

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