A unique gel matrix moisturizer delivers deep hydration resulting in significant clinical improvement in radiance and texture

Julie M. Bianchini, Qihong Zhang, Gabriel Hanna, Carol R. Flach, Hequn Wang, Michael D. Southall, Richard Mendelsohn, Manpreet Randhawa

Research output: Contribution to journalArticlepeer-review


Introduction: As skin ages, it loses its ability to retain moisture and becomes rough and dry. This results in a clinically dull appearance with a loss of radiance, firmness, and suppleness. Symptoms can be improved with use of a moisturizer that builds and maintains skin hydration over time; however, most moisturizers that occlude the skin surface are perceived as heavy and greasy and are not consumer preferred. Methods: A unique, consumer-preferred gel matrix formula was developed by combining liquid crystal structures, which mimic skin barrier lipid assembly, with specific emulsifiers that deliver water deep into skin. Ex vivo studies were conducted to investigate the superior hydrating effects of the gel matrix formula. Confocal Raman microscopy studies assessed the spatial distribution of water in ex vivo skin after application of the gel matrix formula. To determine the effects of the gel matrix formula on dry facial skin, a 12-week clinical study was conducted with subjects with self-perceived skin dryness and dullness. Results: The formulation significantly increased the relative water content throughout epidermal regions, which was not observed with the application of a competitive gel formula. Instrumental measurements assessed improvements in skin surface moisturization and barrier function. Clinical grading showed significant improvements in hydration-related endpoints including radiance, clarity, and texture. Subject self-agree assessment demonstrated that subjects observed improvements in the appearance of their facial skin. Conclusion: These studies demonstrated that the gel matrix formula increased skin water content in deeper layers, and resulted in significant clinical improvements in hydration, barrier function, and clinical appearance of radiance.

Original languageEnglish (US)
Pages (from-to)229-239
Number of pages11
JournalClinical, Cosmetic and Investigational Dermatology
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Dermatology


  • Confocal Raman microscopy
  • Dynamic skin barrier
  • Moisturization
  • Skin hydration
  • Skin radiance


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