A universal allyl linker for solid-phase synthesis

Xiaohu Zhang, Roger A. Jones

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We report synthesis of a universal allyl linker for solid-phase synthesis, 9-O-(4,4'-Dimethoxytrityl)-10-undecenoic (3), that has a reactive terminal double bond. Since allyl cleavage occurs under conditions orthogonal to those used during the solid-phase synthesis and deprotection of DNA or RNA fragments, this linker extends the range of post-synthetic manipulations that can be carried out without cleavage from the support, and means that this linkage could be used to construct affinity columns. Alternatively, it should be possible also to cleave fully protected molecules from the support if so desired.

Original languageEnglish (US)
Pages (from-to)3789-3790
Number of pages2
JournalTetrahedron Letters
Issue number22
StatePublished - May 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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