Abnormal collagen fibrils in nanophthalmos: A clinical and histologic study

Amir Yamani, Irmgard Wood, Ilene Sugino, Maxine Wanner, Marco A. Zarbin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


PURPOSE: To report the successful treatment of choroidal detachment in a patient with nanophthalmos and to report histopathologic findings in this patient's sclera METHODS: Choroidal detachment, secondary angle closure, and nanophthalmos were diagnosed using biomicroscopy, indirect ophthalmoscopy, and echography. Full-thickness sclerectomies in four quadrants were made on the right eye. Sclerae from these sclerectomies were studied ultrastructurally. RESULTS: Best-corrected visual acuity improved to RE, 20/60 from 20/100 preoperatively; the anterior chamber deepened, and the choroidal detachment resolved. Histopathologic studies of each of the three scleral layers disclosed abnormal collagen fibrils that were frayed, split, and contained lightly stained cores. CONCLUSION: New findings include the identification of collagen with lightly stained centers and identification of differences in collagen morphology in different areas of the sclera in a nanophthalmic eye.

Original languageEnglish (US)
Pages (from-to)106-108
Number of pages3
JournalAmerican journal of ophthalmology
Issue number1
StatePublished - Jan 1999

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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