TY - JOUR
T1 - Abnormal collagen fibrils in nanophthalmos
T2 - A clinical and histologic study
AU - Yamani, Amir
AU - Wood, Irmgard
AU - Sugino, Ilene
AU - Wanner, Maxine
AU - Zarbin, Marco A.
N1 - Funding Information:
Supported in part by Research to Prevent Blindness, Inc, New York, New York, and The New Jersey Lions Eye Research Foundation, Newark, New Jersey (M.A.Z.).
PY - 1999/1
Y1 - 1999/1
N2 - PURPOSE: To report the successful treatment of choroidal detachment in a patient with nanophthalmos and to report histopathologic findings in this patient's sclera METHODS: Choroidal detachment, secondary angle closure, and nanophthalmos were diagnosed using biomicroscopy, indirect ophthalmoscopy, and echography. Full-thickness sclerectomies in four quadrants were made on the right eye. Sclerae from these sclerectomies were studied ultrastructurally. RESULTS: Best-corrected visual acuity improved to RE, 20/60 from 20/100 preoperatively; the anterior chamber deepened, and the choroidal detachment resolved. Histopathologic studies of each of the three scleral layers disclosed abnormal collagen fibrils that were frayed, split, and contained lightly stained cores. CONCLUSION: New findings include the identification of collagen with lightly stained centers and identification of differences in collagen morphology in different areas of the sclera in a nanophthalmic eye.
AB - PURPOSE: To report the successful treatment of choroidal detachment in a patient with nanophthalmos and to report histopathologic findings in this patient's sclera METHODS: Choroidal detachment, secondary angle closure, and nanophthalmos were diagnosed using biomicroscopy, indirect ophthalmoscopy, and echography. Full-thickness sclerectomies in four quadrants were made on the right eye. Sclerae from these sclerectomies were studied ultrastructurally. RESULTS: Best-corrected visual acuity improved to RE, 20/60 from 20/100 preoperatively; the anterior chamber deepened, and the choroidal detachment resolved. Histopathologic studies of each of the three scleral layers disclosed abnormal collagen fibrils that were frayed, split, and contained lightly stained cores. CONCLUSION: New findings include the identification of collagen with lightly stained centers and identification of differences in collagen morphology in different areas of the sclera in a nanophthalmic eye.
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U2 - 10.1016/S0002-9394(98)00302-X
DO - 10.1016/S0002-9394(98)00302-X
M3 - Article
C2 - 9933017
AN - SCOPUS:0032902240
SN - 0002-9394
VL - 127
SP - 106
EP - 108
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 1
ER -