Abnormalities of the inactive X chromosome are a common feature of brca1 mutant and sporadic basal-like breast cancer

Shridar Ganesan, A. L. Richardson, Z. C. Wang, J. D. Iglehart, A. Miron, J. Feunteun, D. Silver, D. M. Livingston

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

As a clinical entity, breast cancer appears to be a series of subforms, each with a relatively specific molecular phenotype. Among the characteristics that differentiate these subforms are sex hormone receptor expression, HER2 expression, p53 mutation, high-grade histopathology, and particular gene expression array patterns. Sporadic basal-like breast cancer is one such form. It is a relatively common, high-grade, hormone receptor and HER2-expression- negative, p53 mutation-bearing tumor and is particularly lethal. Although wild type for BRCA1, it is a sporadic phenocopy of most cases of BRCA1-/- breast cancer. Not only do the cells of the two tumors resemble one another with respect to the above-noted characteristics, they also share a defect in the maintenance of an intact, inactive X chromosome (Xi). Other high-grade and most low-grade tumors are rarely defective at Xi. This evidence suggests that an Xi defect contributes to the evolution of both sporadic and BRCA1-/- basal-like breast tumors.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalCold Spring Harbor symposia on quantitative biology
Volume70
DOIs
StatePublished - Dec 1 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

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