Absence of tubular proteinuria following environmental exposure to chromium

Richard P. Wedeen, Syed Haque, Iris Udasin, Patrick C. D'Haese, Monique Elseviers, Marc E. De Broe

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Certain chromium compounds are known to be nephrotoxic, but renal damage from long-term environmental or occupational exposure to chromium has not been documented. To detect possible preclinical renal damage, we tested the urine of 55 lifelong residents of an area contaminated with chromium landfill. The levels of four proteins were determined in urine samples: (1) human intestinal alkaline phosphatase, (2) tissue nonspecific alkaline phosphatase, (3) N-acetyl-β-D-glucosaminidase, and (4) microalbumin. No elevated levels of proteins were found, and there were no significant correlations between urine protein and urine chromium concentrations. We concluded that long-term environmental exposure to chromium dust did not lead to tubular proteinuria.

Original languageEnglish (US)
Pages (from-to)321-323
Number of pages3
JournalArchives of Environmental Health
Issue number4
StatePublished - Aug 1 1996

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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