Absence of urinary tract infection in dogs with experimentally induced hyperadrenocorticism

S. D. Forrester, N. I. Martínez, D. L. Panciera, M. L. Moon, C. R. Pickett, D. L. Ward

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objectives of this study were to determine occurrence of urinary tract infection and describe results of urine analysis and urine culture in dogs with experimentally induced hyperadrenocorticism. Dogs were randomly assigned to receive either hydrocortisone (nine dogs) or placebo (eight dogs) for 49 consecutive days. Before and on day 49 of treatment, evaluation of dogs included physical examination, abdominal ultrasound, urine culture, urinalysis, adrenal function testing, and measurement of urine protein and creatinine and activity of serum alkaline phosphatase. All dogs in the experimental group had clinical and laboratory findings of hyperadrenocorticism. Urine specific gravity was significantly decreased and urine protein-to-creatinine ratio was significantly increased in dogs with hyperadrenocorticism. Urinary tract infection did not occur in any dogs. We conclude that administration of hydrocortisone created a model of hyperadrenocorticism; however, urinary tract infection did not occur. Additional evaluation is needed to determine association between urinary tract infection and hyperadrenocorticism.

Original languageEnglish (US)
Pages (from-to)179-182
Number of pages4
JournalResearch in Veterinary Science
Volume74
Issue number2
DOIs
Publication statusPublished - Apr 1 2003
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • veterinary(all)

Keywords

  • Corticosteroids
  • Hyperadrenocorticism
  • Proteinuria
  • Urinary tract infection
  • Urine protein-to-creatinine ratio

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