Absorbed dose calculations for rapidly growing tumors

R. W. Howell, V. R. Narra, D. V. Rao

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

One of the most promising areas for cancer therapy with administered radiopharmaceuticals is the treatment of very small tumors and micrometastases. Small tumors and micrometastases, however, may be rapidly growing at the time of treatment, resulting in a substantial change in mass during the period of irradiation. In this work, the formalism required to calculate the average absorbed dose to rapidly growing tumors is developed and applied to an in vitro tumor model. Further application to in vivo human myeloma tumors reveals that tumor growth may have a significant effect on the average dose delivered to the tumor from incorporated radionuclides. These considerations may assist in establishing dose-response relationships necessary for radiopharmaceutical cancer therapy.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalJournal of Nuclear Medicine
Volume33
Issue number2
StatePublished - 1992

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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