Acanthosis nigricans - A common significant disorder usually unassociated with malignancy

Robert A. Schwartz, Edmund J. Janniger

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Acanthosis nigricans (AN) can be a highly significant cutaneous finding and is usually unrelated to cancer. It is most often evident as velvety thickening of axillae, posterior neck fold, flexor skin surfaces and umbilicus. It is common in obesity, which is seen increasing in children and adolescents, and can serve as a cutaneous marker of insulin resistance. It is most often associated with hyperinsulinemia, which may result from insulin receptor gene defects causing insulin resistance, and less frequently due to mutations in fibroblast growth factor receptors. In this work non malignancy-associated AN types will be emphasized, particularly the association of AN with insulin-resistance, itself a potential threat to life.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalPrzeglad Dermatologiczny
Issue number1
StatePublished - 2011

All Science Journal Classification (ASJC) codes

  • Dermatology


  • Acanthosis nigricans
  • Drug eruptions
  • Fibroblast growth factor eceptors
  • Insulin receptors
  • Insulin resistance
  • Obesity


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