Access to functionalized steroid side chains via modified Julia olefination

Enver Cagri Izgu, Aaron C. Burns, Thomas R. Hoye

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Various functionalized steroidal side chains were conveniently accessed by a modified Julia olefination strategy using a common sulfone donor and an appropriate α-branched aldehyde acceptor. For the coupling of these hindered classes of reaction partners (and in contrast to typically observed trends), the benzothiazolyl(BT)-sulfone anion gave superior outcomes compared to the phenyltetrazolyl(PT)-sulfone anion.

Original languageEnglish (US)
Pages (from-to)703-705
Number of pages3
JournalOrganic letters
Issue number4
StatePublished - Feb 18 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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