Acetylcholine release in the hippocampus: Effects of cholinergic and GABAergic compounds in the medial septal area

Linda K. Gorman; Kevin Pang; Karyn M. Frick; Ben Givens; David S. Olton

doi:10.1016/0304-3940(94)90485-5

Acetylcholine release in the hippocampus: Effects of cholinergic and GABAergic compounds in the medial septal area

Linda K. Gorman, Kevin Pang, Karyn M. Frick, Ben Givens, David S. Olton

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed using in vivo microdialysis and HPLC-EC. Oxotremorine and scopolamine produced a dose-dependent decrease in hippocampal ACh release. Muscimol decreased hippocampal ACh release at both high and low doses, although not in a dose-dependent manner. The effects of scopolamine and muscimol are consistent with a role of ACh in mnemonic processing.

Original language	English (US)
Pages (from-to)	199-202
Number of pages	4
Journal	Neuroscience Letters
Volume	166
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(94)90485-5
State	Published - Jan 31 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

Keywords

Acetylcholine
GABA
Hippocampus
Intraseptal infusion
Microdialysis

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10.1016/0304-3940(94)90485-5

Cite this

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abstract = "The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed using in vivo microdialysis and HPLC-EC. Oxotremorine and scopolamine produced a dose-dependent decrease in hippocampal ACh release. Muscimol decreased hippocampal ACh release at both high and low doses, although not in a dose-dependent manner. The effects of scopolamine and muscimol are consistent with a role of ACh in mnemonic processing.",

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AU - Pang, Kevin

AU - Frick, Karyn M.

AU - Givens, Ben

AU - Olton, David S.

PY - 1994/1/31

Y1 - 1994/1/31

N2 - The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed using in vivo microdialysis and HPLC-EC. Oxotremorine and scopolamine produced a dose-dependent decrease in hippocampal ACh release. Muscimol decreased hippocampal ACh release at both high and low doses, although not in a dose-dependent manner. The effects of scopolamine and muscimol are consistent with a role of ACh in mnemonic processing.

AB - The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed using in vivo microdialysis and HPLC-EC. Oxotremorine and scopolamine produced a dose-dependent decrease in hippocampal ACh release. Muscimol decreased hippocampal ACh release at both high and low doses, although not in a dose-dependent manner. The effects of scopolamine and muscimol are consistent with a role of ACh in mnemonic processing.

KW - Acetylcholine

KW - GABA

KW - Hippocampus

KW - Intraseptal infusion

KW - Microdialysis

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Acetylcholine release in the hippocampus: Effects of cholinergic and GABAergic compounds in the medial septal area

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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