Achieving molecular diagnostics for Lyme disease

Mark W. Eshoo, Steven E. Schutzer, Christopher D. Crowder, Heather E. Carolan, David J. Ecker

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Early Lyme disease is often difficult to diagnose. Left untreated, symptoms can last for many years leading to chronic health problems. Serological tests for the presence of antibodies that react to Borrelia burgdorferi antigens are generally used to support a clinical diagnosis. Due to the biologically delayed antibody response, serology is negative in many patients in the initial 3 weeks after infection and a single test cannot be used to demonstrate active disease, although certain specialized tests provide strong correlation. Because of these limitations there exists a need for better diagnostics for Lyme disease that can detect Borrelia genomic material at the onset of symptoms.

Original languageEnglish (US)
Pages (from-to)875-883
Number of pages9
JournalExpert Review of Molecular Diagnostics
Volume13
Issue number8
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Keywords

  • Borrelia burgdorferi
  • Lyme disease
  • Lyme disease diagnosis
  • PCR-based assay
  • borreliosis
  • tick-borne disease

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